Prolonged stress can place significant strain on the adrenal glands, impairing their ability to produce essential stress hormones such as cortisol. When the body is exposed to chronic stress, cortisol levels may remain persistently elevated, leading to a range of symptoms including fatigue, low energy, disrupted sleep, irritability, and increased cravings. Over time, this chronic activation can also disrupt the hypothalamic-pituitary-adrenal (HPA) axis, the body’s master regulator of hormone balance. When the HPA axis becomes dysregulated, the effects ripple across multiple systems—impacting metabolism, immune function, mood, digestion, and the sleep-wake cycle.
AnxDefy+ is uniquely formulated to combat the damaging effects of chronic and acute stress by supporting the body’s ability to adapt and recover. Featuring a synergistic blend of nine evidence-backed ingredients, AnxDefy+ addresses not just cortisol regulation but also cognitive function, mood, inflammation, and resilience—making it a comprehensive tool for modern stress management.
N-Acetyl L-Tyrosine (NALT)
NALT plays a critical role in cognitive performance, particularly under stress. As a precursor to catecholamines like dopamine, norepinephrine, and epinephrine, NALT helps support mental alertness, focus, and resilience during fatigue or high-pressure situations. By replenishing neurotransmitter stores depleted by stress, NALT helps maintain sharper thinking and balanced mood. (1)
Relora® (Magnolia and Phellodendron Bark Extract)
Relora is a patented blend shown in clinical trials to lower cortisol levels and reduce symptoms of stress. Research highlights its ability to improve tension, anxiety, depression, anger, fatigue, and confusion, while simultaneously boosting mood and energy. Relora’s unique profile also supports relaxation without sedation and may help curb stress-related eating behaviors. (2)
Choline Bitartrate
Choline is vital for producing acetylcholine, a neurotransmitter responsible for memory, mood, and muscle control. Research suggests that choline supplementation may help reduce anxiety-like behaviors and support cognitive performance, making it particularly relevant for stress resilience. Choline bitartrate is favored for its high bioavailability and efficient absorption. (3)
Rhodiola Extract
Rhodiola rosea is a well-known adaptogenic herb that helps enhance mental and physical performance, reduce fatigue, improve productivity, and combat symptoms of depression. Its antioxidant and anti-inflammatory properties provide additional protection against the oxidative effects of chronic stress. (4)
Ashwagandha
As one of the most studied adaptogens, ashwagandha is known to lower cortisol and may elevate serotonin, improving mood and reducing stress and anxiety. It modulates both the HPA axis and the sympathetic-adrenal-medullary (SAM) axis, which together coordinate the body’s stress response and recovery. (5)
“A staple. These little magic pills are life changing.” – Jaime W.
Holy Basil (Tulsi)
Holy Basil has been shown to reduce stress markers, including cortisol, and may improve sleep quality. Its adaptogenic and anti-inflammatory effects help buffer the body against stress, while also supporting immune health and the regulation of the HPA axis. (6)
L-Theanine
L-theanine, an amino acid found in green tea, has been shown to increase calming neurotransmitters like GABA, dopamine, and serotonin. This leads to greater relaxation, reduced anxiety, and improved focus—without drowsiness. (7)
Turmeric (Curcumin)
While widely known for its anti-inflammatory properties, turmeric’s active compound, curcumin, has also been linked to improvements in mood and mental health. Although not a direct adaptogen, its antioxidant effects may indirectly support resilience to stress by reducing systemic inflammation. (8)
Phosphatidylserine (PS)
Phosphatidylserine has been shown to positively influence mood and lower perceived stress levels. It is particularly effective in individuals experiencing high stress or mild depressive symptoms and may help improve focus and cognitive function under pressure. (9)
By addressing the stress response from multiple angles—neurotransmitter balance, hormone regulation, cognitive support, and inflammation control—AnxDefy+ offers a comprehensive approach to stress management that goes far beyond simple relaxation. Whether you’re managing everyday stress, navigating demanding life phases, or supporting long-term adrenal health, the thoughtful formulation of AnxDefy+ provides a science-backed foundation for resilience and well-being.
The contents of this blog should not be taken as medical advice. It is not intended to diagnose, treat, cure, or prevent any health problem-nor is it intended to replace the advice of a physician. Always consult your physician or qualified health professional on any matters regarding your health. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
References
- https://pmc.ncbi.nlm.nih.gov/articles/PMC1863555/
- https://pubmed.ncbi.nlm.nih.gov/23924268/
- https://pubmed.ncbi.nlm.nih.gov/28642069/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6208354/
- https://pubmed.ncbi.nlm.nih.gov/37832082/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9524226/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6836118/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8863697/
- https://pubmed.ncbi.nlm.nih.gov/11842886/
