Adrenal insufficiency, also known as Addison’s disease, is a serious condition that occurs when the adrenal glands fail to produce enough vital hormones. These hormones—particularly cortisol and aldosterone—are essential for life, and their deficiency can have a profound impact on the body’s ability to manage stress and maintain critical functions.
In fact, stress is a universal experience, and we all know how it can take a toll on our physical and mental health. This is precisely why we created AnxDefy+—a supplement designed to provide additional support for stress management and adrenal health. When stress levels rise, cortisol production increases, which, over time, can negatively affect adrenal function.

Understanding the Role of Adrenal Hormones
The adrenal glands produce two key hormones that play a crucial role in regulating several bodily functions: cortisol and aldosterone.
- Cortisol, often referred to as the "stress hormone," helps the body respond to stress. It also regulates blood pressure, blood sugar, inflammation, and metabolism.
- Aldosterone helps maintain the balance of important minerals such as sodium and potassium, which regulate salt and water balance in the body. This, in turn, keeps blood pressure stable and ensures proper nerve and muscle function, including the heart.
Proper adrenal function and hormonal balance are essential for overall health, particularly in managing stress and maintaining bodily systems. This is where AnxDefy+ can help.
The Stress-Adrenal Connection and the Role of AnxDefy+
AnxDefy+ contains 500mg of N-Acetyl L-Tyrosine (NALT), a bioavailable form of the amino acid tyrosine. Tyrosine plays a vital role in the production of neurotransmitters like dopamine, norepinephrine, and epinephrine, all of which are integral to the body's stress response and mood regulation. These neurotransmitters also influence cortisol levels, potentially helping your body handle stress more effectively. (1)
Addison’s Disease and Rising Autoimmunity
Addison’s disease, though rare, is a form of autoimmune disorder where the immune system attacks the adrenal glands, causing a deficiency in cortisol and aldosterone. This condition, along with other autoimmune diseases, is on the rise globally, with researchers pointing to factors such as changes in diet, environmental toxins, pollution, infections, and increased stress as contributing factors. (2)
Women are more likely than men to develop Addison’s disease, typically between the ages of 30 and 50. Long-term use of glucocorticoid medications like prednisone (used for conditions such as asthma, rheumatoid arthritis, lupus, and inflammation) can also lead to adrenal insufficiency if the medication is stopped abruptly. Corticosteroids suppress the body’s natural production of cortisol, which can, over time, cause the adrenal glands to underperform. (3)

How You Can Support Your Adrenal Health
While many factors contributing to Addison’s disease or other autoimmune conditions are outside of an individual’s control, there are several steps you can take to support your adrenal health. Reducing your toxic load by opting for non-toxic beauty and cleaning products is a good starting point. Similarly, consuming nutrient-dense, organic foods can help minimize the intake of harmful chemicals and pesticides. Eating a balanced diet that is low in processed foods can also reduce inflammation and support the proper functioning of your adrenal glands and hormonal systems. (4)
Stress Management and Hormonal Balance
In today’s fast-paced world, reducing stress can seem like an impossible task, but it is absolutely crucial for maintaining healthy hormone levels. Between work responsibilities, family obligations, and personal health, stress often takes a physical and mental toll. (5)
AnxDefy+ is formulated with 300mg of Relora, a proprietary blend of Magnolia officinalis and Phellodendron amurense. Relora has been extensively studied for its anti-stress properties, showing significant effects in lowering cortisol levels and improving psychological mood states, making it a valuable addition to your wellness routine during high-stress times. (6)
The Bottom Line: Supporting Your Adrenal Health
The adrenal glands play a crucial role in regulating the body’s response to stress, and imbalances in hormones like cortisol and aldosterone can lead to a variety of health challenges, including Addison’s disease. Taking proactive steps to maintain healthy adrenal function, including adding AnxDefy+ to your routine, can help support hormone balance and improve your ability to manage stress effectively.
As always, consult with your healthcare provider before adding any new supplements to your routine. With the right support, you can help maintain your adrenal health and keep stress under control, even during the busiest times of the year.
References:
- National Institutes of Health. (2021). N-Acetyl L-Tyrosine (NALT): Health Benefits.
- The Increasing Prevalence of Autoimmunity and Autoimmune Diseases: An Urgent Call to Action for Improved Understanding, Diagnosis, Treatment and Prevention. PMC
- Epidemiology of Primary and Secondary Adrenal Insufficiency. PubMed
- Low-Grade Inflammation and Ultra-Processed Foods Consumption: A Review. PMC
- Clinical Perspective on Stress, Cortisol, and Adrenal Fatigue. ScienceDirect
- Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on Cortisol and Psychological Mood State in Moderately Stressed Subjects. PMC
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